HBV

Question 1

The presence of anti-HBc in the absence of HBsAg may represent:

A. A false-positive result
B. Past exposure to HBV with resolved or resolving infection
C. Occult chronic HBV infection with detectable HBV DNA
D. All of the above

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Answer 1

D. All of the above

Reference: Huprikar et al. 2015

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Question 2

1 IU = ~5 copies of HBV DNA/ml

True or False?

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Answer 2

True (See FDA guidance pg 8)

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Question 3

Occult hepatitis B virus infection is defined as the presence of HBV DNA in the liver (with or without detectable HBV DNA in the serum) in HBsAg-negative individuals.

True or False?

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Answer 3

True (Samal et al. 2012 pg 146)

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Question 4

Transfusion-transmitted HBV has been reported from a anti-HBs positive occult hepatitis B donor

True or False?

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Answer 4

True (Levicnik-Stezinar et al. 2008)

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